上海儒百生物(Schbio Biotech)
专业血液免疫学产品生产商

Product Description
Human IFN-alpha / beta R1 Protein, Human Fc tag
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Brand : RecProtein®
Synonym : IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1
Molecule : IFNAR1
Catalog : B3253
Qty : 1mg, 5mg
18521561575  需求咨询
Datasheet

Source

Human IFN-alpha/beta R1, Fc Tag   (H-IFNAR1)   is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # NP_000620).

Predicted N-terminus: Lys 28


Molecular Characterization

This protein carries a human IgG1 Fc tag at the C-terminus.


Endotoxin

Less than 0.01 EU/mg by the LAL method.


Purity

>95% as determined by SDS-PAGE.


Bioactivity

ELISA

BIACORE (With our Research Grade Biosimilar Antibody products);


Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.


Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.


Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:

4-8°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.


Background

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.


Reference

(1) Colamonici O., et al., 1994, Mol. Cell. Biol. 14:8133-8142.

(2) Li X., et al., 1997, Mol. Cell. Biol. 17:2048-2056.

(3) Russell-Harde D., et al., 1999, Biochem. Biophys. Res. Commun. 255:539-544.



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