上海儒百生物(Schbio Biotech)
专业血液免疫学产品生产商

Product Description
Human 4-1BB Ligand / TNFSF9 Protein, His tag
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Brand : RecProtein®
Synonym : 4‑1BB Ligand,TNFSF9,CD137L
Molecule : 4‑1BB Ligand
Catalog : B6464
Qty : 1mg, 5mg
18521561575  需求咨询
Datasheet

Source

Human 4-1BB Ligand, His Tag   is expressed from human 293 cells (HEK293)


Endotoxin

Less than 0.01 EU/mg by the LAL method.


Purity

>95% as determined by SDS-PAGE.


Bioactivity

ELISA

BIACORE (With our Research Grade Biosimilar Antibody products);


Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.


Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.


Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:

4-8°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.


Background

Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.


Reference

(1) Won E.Y., et al., 2010, J. Biol. Chem. 285:9202-9210.

(2) Alderson M.R., et al., 1994, Eur. J. Immunol. 24:2219-2227.



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