Product Description

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells within endothelial tissue. However, CD105⁺ cells can also be isolated from human bone marrow. Upon culturing, these CD105⁺ cells show similar characteristics to plastic-adherent mesenchymal stem cells (MSCs). Cultured CD105⁺cells express CD105, CD44, CD29, CD90 and CD106 but do not express CD14, CD34, CD45, or CD31 surface antigens. These cells demonstrate multilineage differential capacity into osteogenic, chondrogenic and adipogenic lineages.

Human bone marrow CD105⁺ cells are positively selected using immunomagnetic anti CD105 microbeads from bone marrow mononuclear cells. Isolated cells are characterized by flow cytometry to ensure a highly pure and viable cell population.

Cells were obtained using Institutional Review Board (IRB) approved consent forms and protocols.

Format	Catalog #	QTY/Unit
Cryopreserved	BM10500.2C BM10500.3C	0.2 million/vial 0.3 million/vial

Product Specification

Species:	Human
Cell Source:	Bone Marrow
Product Type:	Primary Cells
Cell Types:	Endothelial and Mesenchymal Cells
Donor Attributes:	HIV-, HepB-, HepC-
Purity:	≥80% by Flow Cytometry
Viability:	≥85% by Flow CytometryNote: For cryopreserved samples the freeze thaw cycle may decrease cell viability by 10-15% post thaw.
Contains:	Fresh: PBS with 5% FBS and 0.5% BSA Frozen: CryoStor™ CS10 (10% DMSO)