纯度

> 95 % as determined by SDS-PAGE.

内毒素

< 0.01 EU per mg protein as determinedby the LAL method.

蛋白构建

A DNA sequence encoding the mouse Lag3(NP_032505.1) (Met1-Leu442) was expressed with the Fc region of human IgG1 atthe C-terminus.

NP No.

NP_032505.1

表达宿主

HEK293 Cells

种属

Mouse

缓冲液

Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added asprotectants before lyophilization. Specific concentrations are included in thehardcopy of COA.

运输方式

In general, recombinant proteins areprovided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They areshipped out with blue ice unless customers require otherwise.

稳定性 & 储存条件

Samples are stable for up to twelve monthsfrom date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that theprotein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

复溶

A hardcopy of COA with reconstitutioninstruction is sent along with the products. Please refer to it for detailedinformation.

LAG3 Background Information

LAG3, also known as CD223 and Lymphocyteactivation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4extracellular Ig-like domains. The LAG3 gene contains 8 exons. It isselectively expressed in activated T and NK cells. LAG3 has a negativeregulatory function in T cells. It also acts as as a new marker of T cellinduced B cell activation. As a soluble molecule, LAG3 activatesantigen-presenting cells through MHC class II signalling, leading to increasedantigen-specific T-cell