纯度

> 95 % as determined by SDS-PAGE.

内毒素

< 0.01 EU per mg protein as determinedby the LAL method.

蛋白构建

A DNA sequence encoding the mouse CD80(Q00609-1) extracellular domain (Met 1-Lys 245) was fused with the Fc region ofmouse IgG1 at the C-terminus.

表达宿主

HEK293 Cells

种属

Mouse

缓冲液

Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added asprotectants before lyophilization. Specific concentrations are included in thehardcopy of COA.

运输方式

In general, recombinant proteins areprovided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They areshipped out with blue ice unless customers require otherwise.

稳定性 & 储存条件

Samples are stable for up to twelve monthsfrom date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that theprotein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

复溶

A hardcopy of COA with reconstitutioninstruction is sent along with the products. Please refer to it for detailedinformation.

B7-1 Background Information

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD8, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD8 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.